In a conversation with Den of Geek, the writers let slip a nugget of information about the storyline, and it's probably not what Captain America fans would expect....
Markus: "All I’m saying is psychotic 1950s Cap."
The "psychotic 1950s Cap" he simply has to be referring to is William Burnside, aka the Grand Director. He was an obsessed Captain America fan who, along with his own teen sidekick, took on the public and private identity of Steve Rogers and Bucky after discovering the truth behind the Super Soldier serum. Taking part in a new government-sponsored program designed to replace their lost heroes, only to learn that their serum was flawed and had psychotic side-effects. Burnside was placed in suspended animation until he was revived years later as a villain. He was brought back again recently by the Red Skull and tasked with killing the Winter Soldier, who had taken up the mantle of Captain America after Steve Rogers' death. After escaping the Red Skull's grip, Burnside is a man out of time, just like Rogers was upon his awakening. His views on American patriotism are more imperialistic, and he eventually joins a terrorist organization before leaving them and turning to crime-fighting. The serum makes him unstable and unreliable as a hero, but he's hardly a villain in the classic sense.
So here we have another storyline that suggests the Winter Soldier will be sticking around for awhile. It's also another chance to have Captain America examine his place in an increasingly violent and paranoid America, themes which seem to be prevalent in 'The Winter Soldier'.
